Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 14

年份

2023 1

2022 1

2021 1

2020 2

2018 2

2016 1

2015 2

2012 1

2010 2

2002 1

展开︾

关键词

ACE2 1

SARS-CoV-2 1

减阻 1

化学添加剂 1

古生代 1

古近系 1

围着床期 1

坳陷 1

垂直传播 1

有机碳含量 1

油气分布 1

海相油气田 1

盆地 1

石蜡基原油 1

矿物组成 1

管道输送 1

胎儿；先天性心脏病；环境因素 1

胎盘 1

重质原油 1

展开︾

检索范围：

排序：展示方式：

Association of maternal depression with dietary intake, growth, and development of preterm infants: a

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

《医学前沿（英文）》 2018年第12卷第5期页码 533-541 doi: 10.1007/s11684-017-0591-y

摘要：

This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-fullterm (64), non-depression-preterm (70), depression-fullterm (36), and depression-preterm (31). Data on sociodemographic characteristics, nutritional intake, growth, and developmental status of children at 8 months (corrected ages) were collected using a quantitative questionnaire, a 24-Hour Dietary Recall, anthropometric measurements, and the Bayley-III scale. A multivariate analysis was used to evaluate the effects of maternal depression and preterm birth on infant growth and development. The energy, protein, and carbohydrate intake in the depression group was lower than the recommended amounts. The depression preterm groups indicated the lowest Z-scores for length and weight and the lowest Bayley-III scores. Preterm infants of depressed mothers are at high risks of poor growth and development delay.

关键词： maternal depression preterm infant nutrition growth development

HTML PDF 收藏

Astrocytes in depression and Alzheimer’s disease

《医学前沿（英文）》 2021年第15卷第6期页码 829-841 doi: 10.1007/s11684-021-0875-0

摘要： Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In clinical cases, multiple chronic brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer’s disease (AD). For years, complex pathological conditions driven by depression and AD have been widely perceived to contribute to a high risk of disability, resulting in gradual loss of self-care ability, lower life qualities, and vast burden on human society. Interestingly, correlational research on depression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease. As a kind of multifunctional glial cell in the CNS, astrocytes maintain physiological function via supporting neuronal cells, modulating pathologic niche, and regulating energy metabolism. Mounting evidence has shown that astrocytic dysfunction is involved in the progression of depression and AD. We herein review the current findings on the roles and mechanisms of astrocytes in the development of depression and AD, with an implication of potential therapeutic avenue for these diseases by targeting astrocytes.

关键词： astrocytes depression Alzheimer’s disease roles mechanisms

HTML PDF 收藏

Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis

Liping Xuan, Zhiyun Zhao, Xu Jia, Yanan Hou, Tiange Wang, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Lu Qi, Weiqing Wang, Yufang Bi, Min Xu

《医学前沿（英文）》 2018年第12卷第6期页码 678-687 doi: 10.1007/s11684-018-0671-7

摘要：

Type 2 diabetes (T2D) has been associated with a high prevalence of depression. We aimed to determine the causal relation by performing a Mendelian randomization (MR) study using 34 T2D risk genetic variants validated in East Asians as the instrumental variable (IV). An MR analysis was performed involving 11 506 participants from a large longitudinal study. The T2D genetic risk score (GRS) was built using the 34 typical T2D common variants. We used T2D_GRS as the IV estimator and performed inverse-variance weighted (IVW) and Egger MR analysis. The T2D_GRS was found to be associated with depression with an OR of 1.21 (95% CI: 1.07–1.37) after adjustments for age, sex, body mass index, current smoking and drinking, physical activity, education, and marital status. Using T2D_GRS as the IV, we similarly found a causal relationship between genetically determined T2D and depression (OR: 1.84, 95% CI: 1.25–2.70). Though we found no association between the combined effect of the genetic IVs for T2D and depression with Egger MR (OR: 0.95, 95% CI: 0.42–2.14), we found an association for T2D and depression with IVW (OR: 1.75, 95% CI: 1.31–2.46) after excluding pleiotropic SNPs. Overall, the MR analyses provide evidence inferring a potential causal relationship between T2D and depression.

关键词： causal modeling depression Mendelian randomization type 2 diabetes

HTML PDF 收藏

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

《医学前沿（英文）》 2023年第17卷第4期页码 729-746 doi: 10.1007/s11684-022-0978-2

摘要： The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellular carcinoma (HCC). Yes-associated protein 1 (YAP1) expression increased in liver tumor cells in early HCC, and Akkermansia muciniphila abundance decreased in the colon. The response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumors. However, the interaction between A. muciniphila abundance and YAP1 expression remains unclear in HCC. Here, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1 expression in the tumor cells by mice with liver tumors in situ. Mechanistically, hepatocyte-specific Yap1 knockout (Yap1^LKO) maintained bile acid homeostasis in the liver, resulting in an increased abundance of A. muciniphila in the colon. Yap1 knockout enhanced anti-PD-1 efficacy. Therefore, YAP1 inhibition is a potential target for increasing A. muciniphila abundance to promote anti-PD-1 efficacy in liver tumors. Dihydroartemisinin (DHA), acting as YAP1 inhibitor, increased A. muciniphila abundance to sensitize anti-PD-1 therapy. A. muciniphila by gavage increased the number and activation of CD8⁺T cells in liver tumor niches during DHA treatment or combination with anti-PD-1. Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor treatment.

关键词： hepatocellular carcinoma YAP1 Akkermansia muciniphila anti-PD-1 dihydroartemisinin bile acid

HTML PDF 收藏

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

《医学前沿（英文）》 2010年第4卷第2期页码 235-240 doi: 10.1007/s11684-010-0002-0

摘要： This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durations of pregnancy and explore the predictive value of TXB2 for preeclampsia. By employing a prospective and double-blind study method, 180 pregnant women with previously normal blood pressures during their progestation were included in the study. Peripheral venous blood samples were obtained during 10–14 (period I), 20–24 (period II) and 30–34 (period III) weeks of gestation. Maternal serum levels of TXB2 were measured by enzyme-linked immunoassay. The pathogenetic condition and pregnancy outcomes of these cases were observed. (1) Among the 180 previously normotensive women, ten developed preeclampsia (case group; four severe and six mild preeclampsia). One hundred and seventy remained normal till the end of pregnancy (control group). (2) With development of pregnancy, the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen through the Wilcoxon Signed Ranks Test. There was a statistical significance in maternal TXB2 levels between two different gestational stages (<0.01). (3) The levels of maternal serum TXB2 were slightly higher in the case group than in the control group during period I of gestation, but the difference was not statistically significant (>0.05); the levels of TXB2 were significantly higher in the case group than in the control group during periods II and III of gestation (both <0.05). (3) The best cutoff points of maternal TXB2 were 3750 and 4400ng/mL during periods II and III of gestation by receiver operator characteristic (ROC) curve; and the sensitivity, specificity, positive predictive value, negative predictive value and odds radio of TXB2 in predicting preeclampsia were 80%, 69.5%, 13.3%, 98.33%, 9.11 and 90%, 68.82%, 13.84%, 99.13, 19.86, respectively. Higher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared. The maternal serum TXB2 after 20 weeks of gestation had predictive value, and the index after 30 weeks was superior to that prior to 30 weeks .

关键词： thromboxane B2 preeclampsia

HTML PDF 收藏

Molecular regulation and genetic improvement of seed oil content in

Wei HUA,Jing LIU,Hanzhong WANG

《农业科学与工程前沿（英文）》 2016年第3卷第3期页码 186-194 doi: 10.15302/J-FASE-2016107

摘要： As an important oil crop and a potential bioenergy crop, L. is becoming a model plant for basic research on seed lipid biosynthesis as well as seed oil content, which has always been the key breeding objective. In this review, we present current progress in understanding of the regulation of oil content in , including genetics, biosynthesis pathway, transcriptional regulation, maternal effects and QTL analysis. Furthermore, the history of breeding for high oil content in is summarized and the progress in breeding ultra-high oil content lines is described. Finally, prospects for breeding high oil content cultivars are outlined.

关键词： breeding maternal effects oilseed rape QTL

HTML PDF 收藏

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

《医学前沿（英文）》 2022年第16卷第2期页码 227-239 doi: 10.1007/s11684-021-0896-8

摘要： Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesis (AHN), whereas promoting AHN can increase stress resilience against depression. Therefore, investigating the mechanism of neural differentiation and AHN is of great importance for developing antidepressant drugs. The nonpsychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against depression. However, whether CBD can modulate rNSC differentiation and hippocampal neurogenesis is unknown. Here, by using the chronic restraint stress (CRS) mouse model, we showed that hippocampal rNSCs mostly differentiated into astrocytes under stress conditions. Moreover, transcriptome analysis revealed that the FoxO signaling pathway was involved in the regulation of this process. The administration of CBD rescued depressive-like symptoms in CRS mice and prevented rNSCs overactivation and differentiation into astrocyte, which was partly mediated by the modulation of the FoxO signaling pathway. These results revealed a previously unknown neural mechanism for neural differentiation and AHN in depression and provided mechanistic insights into the antidepressive effects of CBD.

关键词： cannabidiol depression radial neural stem cells neurogenesis

HTML PDF 收藏

Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats

null

《医学前沿（英文）》 2015年第9卷第1期页码 82-89 doi: 10.1007/s11684-015-0376-0

摘要：

Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6–15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6–20 pregnant days were significantly different (P<0.01, P<0.05). Significant dose related adverse effects to other reproductive parameters were not seen in F0 and F1, but the number of stillbirths in high dose group showed notably difference compared with the control group (P<0.05), while the litter incidence showed no difference. No Metacavir-associated pathological changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.

关键词： deoxyguanosine analogue Metacavir pregnancy maternal toxicity embryo toxicity teratogenicity

HTML PDF 收藏

易凝高粘原油管输技术及其发展

张劲军

《中国工程科学》 2002年第4卷第6期页码 71-76

摘要：

我国所产原油80%以上为凝点较高的含蜡原油和粘稠的重质原油，其节能、安全输送一直是我国油气储运界面临的主要技术难题。简要介绍了这两类原油的流动特性及机理，概括了原油降凝减阻输送技术研究和应用的现状，分析了其发展趋势，提出了进一步研究需重点解决的问题。预计化学降凝剂改性仍将是含蜡原油节能安全输送技术的发展方向，目前需重点攻克大庆原油改性的难关；稠油乳化降粘减阻技术将得到更多的应用，在我国目前应重点针对海上油田的油水混输管道开展研究。现有技术的提升、新技术的涌现，有赖于基础研究的突破、技术路线的大胆创新和相关。

关键词：管道输送石蜡基原油重质原油降凝减阻化学添加剂

HTML PDF 收藏

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

《医学前沿（英文）》 2020年第14卷第2期页码 193-198 doi: 10.1007/s11684-020-0772-y

摘要： The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6±1.5 weeks, and average birth weight was 3293±425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.

关键词： coronavirus disease 2019 severe acute respiratory syndrome-associated coronavirus maternal-infant infection newborn

HTML PDF 收藏

中国古生代海相油气成藏特征

康玉柱

《中国工程科学》 2010年第12卷第5期页码 11-17

摘要：

1970―1978年笔者在塔里木油气地质调研中首次提出古生代有发育的烃源岩，1984年沙参2井实现了古生代海相油田的首次重大突破。1992年通过多个古生代油气田深入研究建立了古生代海相油气成藏理论。其理论内涵：叠加复合盆地成藏，多时代多层系生油，多期成藏，多时代多类型储盖组合，多成藏模式，油气主要分布在古隆起、古斜坡、断裂带和不整合面附近。

关键词：古生代海相油气田盆地隆起坳陷油气分布

HTML PDF 收藏

母体环境因素暴露与胎儿先天性心脏病病因关系探讨

刘艳,黄鹏,孙晓如,林宁,喻荣彬,石慧,王丽娟

《中国工程科学》 2015年第17卷第6期页码 41-44

摘要：

探讨先天性心脏病与患儿母亲孕前及孕期环境因素暴露的关系。对先天性心脏病患儿的母亲面对面结构式访谈，填写调查问卷，共回收有效问卷373份，其中病例组157例，对照组216例。并分析孕前及孕期环境危险因素对胎儿先天性心脏病的影响。有先天性心脏病家族史、患儿母亲有流产史、不良妊娠史、孕期农药接触史、孕早期患病、孕早期用药、孕期胎儿异常与生育先天性心脏病患儿关系显著（P<0.05）。改善母亲健康状况，控制或减少工作生活环境中危险因素暴露，加强孕期检查，对于降低胎儿先天性心脏病发生风险尤为重要。

关键词：胎儿；先天性心脏病；环境因素

HTML PDF 收藏

济阳坳陷渤南洼陷页岩油气形成条件研究

张善文,王永诗,张林晔,李政, 朱家俊,巩建强,郝运轻

《中国工程科学》 2012年第14卷第6期页码 49-55

摘要：

通过大量地震、钻井、测井、矿物、地球化学、物性资料分析，认为济阳坳陷渤南洼陷古近系沙一段、沙三下和沙四上亚段页岩分布面积广，有机质丰度高，有机质类型以I—II型为主，有机质成熟度分布范围宽，具备形成大量页岩油气的物质基础，三套泥页岩全岩矿物组成中粘土矿物含量低，脆性矿物含量高，以碳酸盐含量为主，利于页岩油气的开采。页岩中压力系数高，各类微孔隙、微裂缝发育，从而容易形成网状的油气储存体系，利于页岩油气的保存。含油、水饱和度分析资料显示，渤南洼陷沙三下亚段12上—13上层组页岩中具有较高的单位岩石含油气量，是页岩油气勘探的有利层段，其中的纹层状泥质灰岩是最有利的岩石类型，具有较好的页岩油气勘探前景。

关键词：页岩油气古近系陆相页岩矿物组成有机碳含量

HTML PDF 收藏

SARS-CoV-2 侵入因子——ACE2 和TMPRSS2 在围着床期胚胎和母胎界面存在表达 Article

陈伟,袁鹏,杨铭,严智强,孔思明,严杰,柳溪溪,陈依东,乔杰,闫丽盈

《工程（英文）》 2020年第6卷第10期页码 1162-1169 doi: 10.1016/j.eng.2020.07.013

摘要：

在全球肆虐的严重急性呼吸系统综合征冠状病毒2（severe acute respiratory syndrome coronavirus 2,SARS-CoV-2）导致了大量人群感染，血管紧张素转化酶2（angiotensin-converting enzyme 2, ACE2）是SARS-CoV和SARS-CoV-2的受体蛋白。然而是否存在SARS-CoV-2的垂直传播仍颇有争议。为了探讨SARS-CoV-2垂直传播的潜在风险，我们利用已发表的单细胞转录组数据观察了围着床期胚胎和母胎界面上ACE2和TMPRSS2（编码跨膜丝氨酸蛋白酶2）的转录表达情况。结果显示，ACE2和TMPRSS2在第6天（D6）围着床期胚胎的滋养外胚层（trophectoderm, TE）细胞、妊娠第8周的合胞滋养层（syncytiotrophoblast at 8 weeks of gestation, STB_8W）细胞以及妊娠第24周的绒毛外滋养层（extravillous trophoblasts at 24 weeks of gestation, EVT_24W）细胞中均存在明显的共表达现象，表明这些细胞类群可能易被SARS-CoV-2感染。在这三个细胞类群中，ACE2阳性表达细胞相对于阴性细胞在自噬和免疫相关过程中存在差异。尽管ACE2的表达水平在围着床期胚胎中没有表现出性别偏差，但是其在D6 TE、第6天围着床期胚胎的原始内胚层（D6 primitive endoderm, D6 PE）细胞以及ACE2阳性表达的STB细胞中存在明显的性别差异。这表明围着床期发育第6天以及妊娠期胚胎对SARS-CoV-2的易感性可能存在性别差异。我们的结果揭示了胚胎移植过程中，围着床期以及妊娠期胚胎面临着SARSCoV-2的潜在感染风险。

关键词： SARS-CoV-2 ACE2 垂直传播胎盘围着床期